hrp0086p1-p897 | Thyroid P1 | ESPE2016

Congenital Hypothyroidism: The Use of a TSH Cut-off Limit of 6mU/L and the ESPE Criteria for LT4 Treatment Leads to the Diagnosis of Mild but mostly Permanent Forms of Hypothyroidism

Gika Anna , Iliadi Alexandra , Platis Dimitris , Giogli Vasiliki , Arditi Jessica , Tzifi Flora , Kyrimis Taxiarchis , Vasilakis Ioannis , Chrousos George , Girginoudis Panagiotis , Kanaka-Gantenbein Christina , Voutetakis Antonis

Background: Since the initiation of neonatal screening programs for Congenital Hypothyroidism (CH) in the 1970’s, a gradual decrease of TSH cut-off limits has been observed worldwide. Nevertheless, lack of universal consensus has led to wide variation of cut-off limits and LT4 therapy criteria among screening programs, even within the same country. The Greek neonatal CH screening program is carried out by a single laboratory that uses one of the lowest cut-off limits worl...